Sponsor Kapoorlabs-CAPED

🔬 Bridging Physics and Biology for Drug Discovery

We're applying non-equilibrium statistical mechanics to decode how cells make decisions, respond to environments, and how diseases emerge.

The Vision

Living systems exist far from thermodynamic equilibrium - dynamic, energy-consuming processes. Yet most biological analysis treats them as static. We're changing that.

Our image analysis tools bridge biology and physics, transforming microscopy data into quantitative trajectories that enable physics-based theories for drug discovery.

🎯 What We Do

Image Analysis Bridge: 3D segmentation • Deep learning models (StarDist, CARE, U-Net, VollSeg, CellPose) • Cell state detection (mitosis, apoptosis) • Automated lineage correction • Morphodynamic feature extraction

Physics-Based Analysis: Single-cell trajectory analysis • Non-equilibrium statistical mechanics • Mean squared displacement • Cell fate prediction

Drug Discovery Goal: Identify critical intervention points • Predict cellular responses • Discover therapeutic targets based on physical principles

💡 Why This Matters

Traditional drug discovery is expensive, slow, and has high failure rates. Physics-grounded understanding enables predictions that generalize, identifies universal cellular principles, and opens new therapeutic strategies. Open source accelerates science — our tools are freely available worldwide.

🤝 Sponsorship Tiers

$1,200/month - Quarterly Collaboration ⭐️

Minimum 3 months. For academics needing custom analysis:

• Custom Fiji & Python code • Interactive UIs (Jupyter, Napari, Fiji, TrackMate) • Direct analyst collaboration • PDF reports & Zoom updates • Slack support • GPU/CPU resources included • You own all code, data, models, publications

Annual: $12,000/year (save $2,400)

$5,000/month - Research Patron

Quarterly progress reports • Early tool access • Publication acknowledgment • Slack access • Custom pipeline development • Strategic input • Quarterly retreats • Co-authorship opportunities • Naming rights • Full ownership

Annual: $50,000/year (save $10,000)

Academic Service Menu: AImage Analysis Airport ✈️

Software packages native to your HPC, Desktop, or Laptop:

1. Custom training data for 3D segmentation (nuclei, membranes, structures)
2. 3D deep learning models (StarDist, CARE, U-Net, VollSeg, AutoEncoder, CellPose)
3. ONEAT models for cell state detection (mitosis, apoptosis, necrosis)
4. Automatic lineage tree correction in TrackMate using biological knowledge
5. TrackMate XML to DataFrame conversion with shape and dynamic information
6. Unsupervised, XGBoost, or CNN-attention models for cell fate classification
7. Inception-style models for improved prediction accuracy
8. Non-equilibrium statistical mechanics applied to single-cell trajectories
9. Custom analyses: recoil velocity, mean squared displacement, Napari plugins

Resources:

• Published Workflow
• Workflow Code
• Documentation

📊 Impact

Open-source tools used by researchers worldwide • Custom models for segmentation, cell states, trajectories • Active development of non-equilibrium physics frameworks • Collaborations in cancer, development, and drug discovery research

"The living cell is a far-from-equilibrium system. To understand it, we must speak its language - the language of physics."